Journal article
Chemically modified and conjugated antimicrobial peptides against superbugs
W Li, F Separovic, NM O'Brien-Simpson, JD Wade
Chemical Society Reviews | ROYAL SOC CHEMISTRY | Published : 2021
DOI: 10.1039/d0cs01026j
Abstract
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacterial infections than cancer. New antimicrobial agents, both broad-spectrum and selective, that do not induce AMR are urgently required. Antimicrobial peptides (AMPs) are a novel class of alternatives that possess potent activity against a wide range of Gram-negative and positive bacteria with little or no capacity to induce AMR. This has stimulated substantial chemical development of novel peptide-based antibiotics possessing improved therapeutic index. This review summarises recent synthetic efforts and their impact on analogue design as well as their various appli..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
The authors gratefully acknowledge the financial support by the National Health and Medical Research Council (NHMRC) of Australia and Australian Research Council (ARC) over many years for the peptide chemistry and chemical biology studies reported in the authors' laboratories. NMOS is the recipient of funding from NHMRC (APP1142472, APP1158841, APP1185426), ARC (DP210102781, DP160101312, LE200100163), Cancer Council Victoria (APP1163284) and Australian Dental Research. Funding in antimicrobial materials and research is supported by the Centre for Oral Health Research at The Melbourne Dental School. JDW is an NHMRC Principal Research Fellow (APP1117483) and the ARC (DP120100654). The studies undertaken in his laboratory was supported by an NHMRC Project grant (APP1158841). WL is the recipient of the Weary Dunlop Foundation grant and 2020 Early Career Researcher grant scheme of the University of Melbourne. Research at The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program.